Sequence Analysis of Rat Liver Uricase-cDNA and the Possible Presence of the Homologous cDNA Sequences in Chicken Embryo
The final product of purine nucleotide metabolism varies from uric acid to ammonia, depending on the species, and it is supposed that the enzymes responsible for the degradation of uric acid have been lost one by one during evolution (1). The loss of the enzymes could be due to the inactivation of the genes. Therefore, in order to understand the mechanism of the gene inactivation, we tried to isolate cDNAs for uricase in various species and compare their structures.
KeywordsUrea Agarose Polypeptide Nylon Pyrimidine
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