Selective Inhibition of Cytotoxic T Lymphocyte Proliferation by Mizoribine (Bredinin), an Adenosine Analog
Since a number of patients with severe combined immunodeficiency syndrome have been found to be deficient in adenosine deaminase (ADA) or purine nucleotide phosphorylase (PNP)(1, 2), purine metabolism has been postulated to be deeply involved in human immune system. A series of evidences has shown that abnormally accumulated purine deoxynucleosides in these patients have selective toxicity on T or B lymphocytes. Another experiments demonstrated critical roles of purine enzymes on lymphocyte maturation or differentiation. (3, 4, 5).
KeywordsPeripheral Blood Lymphocyte Lymphocyte Subpopulation Mycophenolic Acid Purine Metabolism Purine Analog
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