Activity of 2-Chloro-2′-Deoxyadenosine in Chronic Lymphocytic Leukemia, Hairy Cell Leukemia, and Autoimmune Hemolytic Anemia

  • Dennis A. Carson
  • Lawrence D. Piro
  • D. Bruce Wasson
  • Carlos J. Carrera
  • Ernest Beutler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 253A)


Interest in the pathways of nucleotide metabolism in human lymphocytes was stimulated by the serendipitous observations of Giblett, et al., who found that two inborn errors of purine nucleoside metabolism cause severe impairment of lymphocyte function, while sparing other cell types (1, 2). A genetic deficiency of adenosine deaminase engenders a combined immunodeficiency syndrome (1). A similar deficiency in purine nucleoside phosphorylase is associated with a selective cellular immune deficit (2).


Chronic Lymphocytic Leukemia Adenosine Deaminase Chronic Lymphocytic Leukemia Patient Hairy Cell Leukemia Chronic Lymphocytic Leukemia Cell 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Dennis A. Carson
    • 1
  • Lawrence D. Piro
    • 1
  • D. Bruce Wasson
    • 1
  • Carlos J. Carrera
    • 1
  • Ernest Beutler
    • 1
  1. 1.Department of Basic and Clinical ResearchResearch Institute of Scripps ClinicLa JollaUSA

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