Changes in Trophoblastic Purine Metabolism with Aging of the Placenta
In rapidly growing and metabolically highly active tissues, such as those of the human feto-placental unit, large amounts of purine nucleotides are required. The role of the placenta in the feto-placental purine metabolism as well as the details of placental, and especially trophoblastic, purine metabolism, and their possible changes with gestation are, however, largely unknown.
KeywordsAdenine Nucleotide Trophoblastic Cell Precursor Concentration Purine Nucleotide Adenylate Energy Charge
Unable to display preview. Download preview PDF.
- Atkinson, D.E., 1977, Cellular Energy Metabolism and Its Regulation, Acad Press, N.Y.Google Scholar
- Gabbe, S.G., Demers, L.A., Creep, R.O., and Villee, C.A., 1972, The effects of hypoxia on placental glycogen metabolism, Am J Obstet Gynecol, 114: 540.Google Scholar
- Roux, J.F., and Villee, C.A., 1960, Effects of anoxia on the metabolism of the human placenta in vitro, Am J Obstet Gynecol, 80: 224.Google Scholar
- Vettenranta, K., and Raivio, K.O., 1988b, Adenine nucleotide catabolism in the human trophoblast early and late in gestation, Pediatr Res, in press.Google Scholar