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Changes in Trophoblastic Purine Metabolism with Aging of the Placenta

  • Kari O. Raivio
  • Kim Vettenranta
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 253A)

Abstract

In rapidly growing and metabolically highly active tissues, such as those of the human feto-placental unit, large amounts of purine nucleotides are required. The role of the placenta in the feto-placental purine metabolism as well as the details of placental, and especially trophoblastic, purine metabolism, and their possible changes with gestation are, however, largely unknown.

Keywords

Adenine Nucleotide Trophoblastic Cell Precursor Concentration Purine Nucleotide Adenylate Energy Charge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Atkinson, D.E., 1977, Cellular Energy Metabolism and Its Regulation, Acad Press, N.Y.Google Scholar
  2. Brunette, M.G., and Allard, S., 1985, Phosphate uptake by syncytial brush border membranes of human placenta, Pediatr Res, 19: 1179.PubMedCrossRefGoogle Scholar
  3. Crabtree, G.V., and Henderson, J.F., 1971, Rate-limiting steps in the interconversion of purine ribonucleotides in Ehrlich ascites tumor cells in vitro, Cancer Res, 31: 985.PubMedGoogle Scholar
  4. Gabbe, S.G., Demers, L.A., Creep, R.O., and Villee, C.A., 1972, The effects of hypoxia on placental glycogen metabolism, Am J Obstet Gynecol, 114: 540.Google Scholar
  5. Gabbe, S.G., and Villee, C.A., 1971, The effect of hypoxia on progesterone synthesis by placental villi in organ culture, Am J Obstet Gynecol, 111: 31.PubMedGoogle Scholar
  6. Hauguel, S., Challier, J.-C., Cedard, L., and Olive, G., 1983, Metabolism of the human placenta perfused in vitro: glucose transfer and utilization, O2 consumption, lactate and ammonia production, Pediatr Res, 17: 729.PubMedCrossRefGoogle Scholar
  7. Hershfield, M.S., and Seegmiller, J.E., 1976, Regulation of de novo purine biosynthesis in human lymphoblasts, J Biol Chem, 251: 7348.PubMedGoogle Scholar
  8. Illsley, N.P., Aarnoudse, J.G., Penfold, P., Bardsley, S.E., Coade, S.B., Stacey, T.E., and Hytten, F.E., 1984, Mechanical and metabolic viability of a placental perfusion system in vitro under oxygenated and anoxic conditions, Placenta, 5: 213.PubMedCrossRefGoogle Scholar
  9. Longo, L.D., Yuen, P., and Gusseck, D.J., 1973, Anaerobic, glycogen-dependent transport of amino acids by the placenta, Nature Lond., 243: 531.PubMedCrossRefGoogle Scholar
  10. Müller, M.M., Kraupp, M., Chiba, P., and Rumpold, H., 1983, Regulation of purine uptake in normal and neoplastic cells, Adv Enzyme Regul, 21: 33.CrossRefGoogle Scholar
  11. Peterson, G.L., 1977, A simplification of the protein assay method of Lowry et al., which is more generally applicable, Anal Biochem, 83: 346.PubMedCrossRefGoogle Scholar
  12. Pettersson, K., Siitari, H., Hemmilä, I., Soini, E., Lövgren, T., Hänninen, V., Tanner, P., and Stenman, U.-H., 1983, Time-resolved fluoroimmunoassay of human choriogonadotropin, Clin Chem, 29: 60.PubMedGoogle Scholar
  13. Roux, J.F., and Villee, C.A., 1960, Effects of anoxia on the metabolism of the human placenta in vitro, Am J Obstet Gynecol, 80: 224.Google Scholar
  14. Sakurai, T., Tagaki, H., and Hosoya, N., 1969, Metabolic pathways of glucose in human placenta, Am J Obstet Gynecol, 105: 1044.PubMedGoogle Scholar
  15. Vettenranta, K., and Raivio, K.O., 1988a, Activities of key enzymes of purine degradation and reutilization in human trophoblastic cells, Placenta, 9: 27.PubMedCrossRefGoogle Scholar
  16. Vettenranta, K., and Raivio, K.O., 1988b, Adenine nucleotide catabolism in the human trophoblast early and late in gestation, Pediatr Res, in press.Google Scholar
  17. Virtanen, I., Lehto, V.-P., Lehtonen, T., Vartio, T., Stenman, S., Kurki, P., Wager, O., Small, J.V., Dahl, D., and Badley, R.A., 1981, Expression of intermediate filaments in cultured cells, J Cell Sci, 50: 45.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Kari O. Raivio
    • 1
  • Kim Vettenranta
    • 1
  1. 1.Children’s HospitalUniversity of HelsinkiFinland

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