Degradation of Purine Nucleosides by Mitochondrial Enzymes of Bovine Liver

  • Roger A. Lewis
  • Laura Link
  • Wilbert Chen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 253A)


In recent years, it was shown that mitochondria actively metabolize purine deoxynucleosides. It was documented that both deoxyguanosine and deoxyadenosine were phosphorylated by mitochondrial enzymes (1–6). In the case of deoxyguanosine, intact mitochondria formed dGMP, dGDP and dGTP (3, 5). dAMP was detected in intact mitochondria which were supplemented with deoxyadenosine (6). Regarding the degradation of purine deoxynucleosides by mitochondrial enzymes, adenosine deaminase activity was noted in intact and fractured mitochondria (6, 7).


Adenosine Deaminase Mitochondrial Enzyme Purine Nucleoside Purine Nucleoside Phosphorylase Ammonium Sulfate Fraction 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Roger A. Lewis
    • 1
  • Laura Link
    • 1
  • Wilbert Chen
    • 1
  1. 1.Department of BiochemistryUniversity of Nevada-RenoRenoUSA

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