Purine Metabolites as Measures of Birth Asphyxia and Predictors of Brain Damage

  • Vineta J. Ruth
  • Kari O. Raivio
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 253A)


The term asphyxia is generally used to describe the combination of hypoxia, hypercarbia, and ischemia. This situation may have an acute onset as a result of delivery complications, or it may be a chronic condition, usually caused by placental dysfunction. Asphyxia occurs in 1–7% of all deliveries. The major neurologic sequelae of asphyxia frequently cause a handicap and consist of cerebral palsy, hydrocephaly, and seizure disorders. In a population-based study, the incidence of cerebral palsy of perinatal origin was 1.1 per 1000 live births, and 47% of the handicapped infants had been born at term (Hagberg et al. 1984).


Uric Acid Cerebral Palsy Apgar Score Birth Asphyxia Developmental Quotient 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Vineta J. Ruth
    • 1
  • Kari O. Raivio
    • 1
  1. 1.Children’s HospitalUniversity of HelsinkiHelsinkiFinland

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