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Enhanced Adenine Nucleotide Degradation in Chronic Obstructive Pulmonary Disease: The Effect of Oxygen Therapy

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Purine and Pyrimidine Metabolism in Man VI

Abstract

Cellular metabolism requires a continuous energy supply that is furnished largely by adenosine triphosphate (ATP). ATP is synthesized in the mitochondrial electron transport chain from adenosine diphosphate (ADP), inorganic phosphate, NADH and oxygen. Since 80–90% of total oxygen consumption in humans is destined to the synthesis of high-energy compounds, oxygen availability is essential for cellular ATP recharge.

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© 1989 Plenum Press, New York

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Mateos, F.A., Gómez, P.F., Puig, J.G., Jiménez, M.L., Ramos, T.H., Mantilla, J.G. (1989). Enhanced Adenine Nucleotide Degradation in Chronic Obstructive Pulmonary Disease: The Effect of Oxygen Therapy. In: Mikanagi, K., Nishioka, K., Kelley, W.N. (eds) Purine and Pyrimidine Metabolism in Man VI. Advances in Experimental Medicine and Biology, vol 253A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5673-8_54

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  • DOI: https://doi.org/10.1007/978-1-4684-5673-8_54

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5675-2

  • Online ISBN: 978-1-4684-5673-8

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