Renal Handling of Hypoxanthine and Xanthine in Normal Subjects and in Cases of Idiopathic Renal Hypouricemia

  • Kiyoko Kaneko
  • Shin Fujimori
  • Takaaki Kanbayashi
  • Ieo Akaoka
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 253A)


Four components are involved in the renal excretion of uric acid in humans1–8, these being glomerular filtration, presecretory reabsorption, tubular secretion and postsecretory reabsorption. The renal transport of hypoxanthine and xanthine has been reported only for a xanthinuric patient9, but has not been shown for normal subjects mainly because of the low concentrations of these substances in normal body fluids.


Uric Acid Suppression Rate Tubular Secretion Renal Handling Uric Acid Excretion 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Kiyoko Kaneko
    • 1
  • Shin Fujimori
    • 1
  • Takaaki Kanbayashi
    • 1
  • Ieo Akaoka
    • 1
  1. 1.2nd Department of Internal MedicineTeikyo University School of MedicineTokyoJapan

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