Renal Handling of Hypoxanthine and Xanthine in Normal Subjects and in Cases of Idiopathic Renal Hypouricemia
Four components are involved in the renal excretion of uric acid in humans1–8, these being glomerular filtration, presecretory reabsorption, tubular secretion and postsecretory reabsorption. The renal transport of hypoxanthine and xanthine has been reported only for a xanthinuric patient9, but has not been shown for normal subjects mainly because of the low concentrations of these substances in normal body fluids.
KeywordsUric Acid Suppression Rate Tubular Secretion Renal Handling Uric Acid Excretion
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- 5.Vries A, Sperling O: Inborn hypouricemia due to isolated renal tubular defect. Biomed 1979; 30: 75–80Google Scholar