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Renal Excretion of Purine Bases — Effects of Probenecid, Benzbromarone and Pyrazinamide

  • Toshikazu Hada
  • Tetsuya Yamamoto
  • Yuji Moriwaki
  • Sumio Takahashi
  • Kazuya Higashino
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 253A)

Abstract

The renal transport mechanism(s) of oxypurines has been investigated by many workers1–4. As a result, it has been demonstrated that a mechanism for both renal reabsorption and secretion of oxypurines is present in the human. However, a transport mechanism for oxypurines has not yet been accurately or reliably hypothesized, lacking the base of many investigations. We therefore conducted investigations on the renal transport mechanism of oxypurines by employing uricosuric agents (probenecid and benzbromarone) and pyrazinamide.

Keywords

Uric Acid Transport Mechanism Xanthine Oxidase Renal Excretion Control Period 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Toshikazu Hada
    • 1
  • Tetsuya Yamamoto
    • 1
  • Yuji Moriwaki
    • 1
  • Sumio Takahashi
    • 1
  • Kazuya Higashino
    • 1
  1. 1.The Third Department of Internal MedicineHyogo College of MedicieneNishinomiya, Hyogo 663Japan

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