Renal Excretions of Oxypurinol and Oxypurines — Effects of Pyrazinamide, Probenecid and Benzbromarone

  • Tetsuya Yamamoto
  • Yuji Moriwaki
  • Sumio Takahashi
  • Toshikazu Hada
  • Kazuya Higashino
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 253A)


In normal persons and gouty subjects, allopurinol is mainly converted to oxypurinol by xanthine oxidase and oxypurinol is then excreted unchanged by the kidney1. The concentration of serum oxypurinol is directly related to the renal clearance of oxypurinol2, which is increased or decreased under various conditions2, 3. While the renal handling of oxypurinol seems to be similar to that of uric acid 2, 4, the renal transport mechanism(s) of oxypurinol has not yet been clearly elucidated. Therefore, in this work we studied the renal handling of oxypurinol together with oxypurines using uricosuric agents (probenecid and benzbromarone) and pyrazinamide which affect the renal transport of uric acid.


Uric Acid Xanthine Oxidase Renal Excretion Control Period Purine Nucleoside 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Tetsuya Yamamoto
    • 1
  • Yuji Moriwaki
    • 1
  • Sumio Takahashi
    • 1
  • Toshikazu Hada
    • 1
  • Kazuya Higashino
    • 1
  1. 1.The Third Department of Internal MedicineHyogo College of MedicineNishinomiya, Hyogo 663Japan

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