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Impaired Renal Excretion of Hypoxanthine and Xanthine in Primary Gout

  • Juan G. Puig
  • Felícitas A. Mateos
  • Manuel L. Jiménez
  • Teresa Ramos
  • Ma. C. Capitán
  • Antonio A. Gil
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 253A)

Abstract

Most patients with primary gout show a relative underexcretion of uric acid when compared to normal subjects (1–3). It has been suggested that an alteration in the tubular transport of uric acid could reflect a more extensive defect which might involve related compounds (4). Hypo-xanthine and xanthine are intermediates of the purine nucleotide degradation pathway. Disturbances of hypoxanthine and xanthine metabolism may provide important insights for better understanding the mechanism underlying primary gout.

Keywords

Uric Acid Serum Urate Level Uric Acid Excretion Uric Acid Production Plasma Urate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Juan G. Puig
    • 1
  • Felícitas A. Mateos
    • 1
  • Manuel L. Jiménez
    • 1
  • Teresa Ramos
    • 1
  • Ma. C. Capitán
    • 1
  • Antonio A. Gil
    • 1
  1. 1.Departments of Internal Medicine and Clinical Biochemistry “La Paz” HospitalUniversidad AutónomaMadridSpain

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