Activity and Effect of Purine Metabolizing Enzymes in the Digestive Tract
The relationship between dietary factors and the prevalence of gout is well known. During World Wars I and II, acute gouty arthritis was observed to be uncommon in Europe. In Japan, recently, gout is becoming more common perhaps due to an increased intake of protein and purines. Many gouty patients eat food rich in purines and excrete increased urinary urate. It seems that dietary purines may be easily absorbed from the intestinal tract and may be degraded to uric acid in the liver.
KeywordsUric Acid Xanthine Oxidase Adenosine Deaminase Purine Nucleoside Phosphorylase Xanthine Oxidase Activity
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