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Behavior of Oxypurines in Normal Subjects After an 8 Day Purine-Free Diet

  • Enrico Marinello
  • Brunetta Porcelli
  • Daniela Vannoni
  • Anna Taddeo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 253A)

Abstract

We have already reported1 that gouty patients have a tendency to higher urinary levels excretion of purine bases in comparison to normal subjects. Since diet plays a very important role in this pathology, we analyzed the behavior of oxypurines (hypoxanthine and xanthine) and uric acid in gouty subjects after an 8 day purine-free diet (this diet is reported in table 1). This type of diet limits the ingestion of preformed purines to add to the burden of the uric acid pool and urinary disposal, as well as the ingestion of dietary constituents which can promote endogenous production of purines.2

Keywords

High Performance Liquid Chromatography Uric Acid Purine Base Uric Acid Excretion Primary Gout 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    M. F. Aleo, G. Pompucci, M. S. D’Amato, R. Marcolongo and E. Marinello, The behavior of oxypurines in human primary gout; Quad. Sclavo Diagn. 18: 235 (1983)Google Scholar
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    M. J. MacLachlan and G.P. Rodnan, Effects of food fast and alcohol on serum uric acid and acute attacks of gout, Am. J. Med. 42: 38 (1967)PubMedCrossRefGoogle Scholar
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    B. A. Barnes, O. Cope and T. Harrison, Magnesium conservation in human beings on low magnesium diet, J. Clin. Invest. 37: 430 (1958)PubMedCrossRefGoogle Scholar
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    M. G. Fitzgerald and P. Fourman, An experimental study of magnesium deficiency in man, Clin. Sci. 15: 635 (1965)Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Enrico Marinello
    • 1
  • Brunetta Porcelli
    • 1
  • Daniela Vannoni
    • 1
  • Anna Taddeo
    • 1
    • 2
  1. 1.Institute of Biological ChemistryUniversity of SienaItaly
  2. 2.Institute of RheumatologyUniversity of SienaItaly

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