Is Gout Related to an Alteration of the Uric Acid Protein Binding?
For more than a century, increased serum uric acid (U.A.) levels have been known to be a risk factor for gout1. However, although many hyperuricemic subjects have U.A. concentrations that exceed the estimate solubility of urate in serum, only about 25% of them appear to develop clinical gout2.
KeywordsUric Acid Serum Uric Acid Chronic Renal Disease Gouty Arthritis Gout Attack
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- 7.G. Morozzi, M.S. D’Amato, A. Fioravanti, A. Renieri, A. Taddeo, R. Marcolongo: The sex steroids influence on uric acid binding to human plasma-proteins, in “Purine and Pyrimidine Metabolism in Man, Part A”, W.L. Nyhan, L.F. Thompson and W.E. Watts, eds. Plenum Publishing Corporation, New York 1986, pag. 393CrossRefGoogle Scholar
- 10.J.R. Klinenberg: The management of asymptomatic hyperuricaemia, Clin. Rheum. Dis. 3: 159, (1977)Google Scholar