The Solubility of Uric Acid and Monosodium Urate in Urine

  • Toru Shimizu
  • Mineko Nishikawa
  • Hiroshi Matsushige
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 253A)


Urinary management including regulation of uric acid excretion and urinary pH is an important consideration along with the control of the serum urate level in the treatment of gout or hyperuricemia. For appropriate management of urine, accurate evaluation of the solubility of urate, as well as that of uric acid, is necessary, because the greater portion of uric acid exists in the form of urate in the physiological range of urinary pH.


Uric Acid Calcium Oxalate Urate Anion Uric Acid Concentration Serum Urate Level 


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  1. 1.
    J. P. Peters and D. D. Van Slyke, Uric Acid, in: “Quantitative Clinical Chemistry”, Williams and Wilkins Co. LTD., Baltimore (1937)Google Scholar
  2. 2.
    W. R. Wilcox, A. Khalaf, A. Weinberger, I. Kippen, and J. R. Klinenberg, Solubility of uric acid and monosodium urate, Med & Biol Eng 10: 522 (1972)CrossRefGoogle Scholar
  3. 3.
    I. Kippen, J. R. Klinenberg, A. Weinberger, and W. R. Wilcox, Factors affecting urate solubility in vitro, Ann Rheum Dis 33: 313 (1974)PubMedCrossRefGoogle Scholar
  4. 4.
    C. Y. C. Pak, O. Waters, L. Arnold, K. Holt, C. Cox, and D. Barilla, Mechanism for calcium urolithiasis among patients with hyperuricos-uria, J Clin Invest 59: 426 (1977)PubMedCrossRefGoogle Scholar
  5. 5.
    R. A. McNabb and F. M. A. McNabb, Physiological chemistry of uric acid, Comp Biochem Physiol 67A: 27 (1980)CrossRefGoogle Scholar
  6. 6.
    F. L. Coe, R. L. Lawton, P. B. Goldstein, and Y. Tembe, Sodium urate accelerates precipitation of calcium oxalate in vitro, Proc Soc Exp Biol Med 149: 926 (1975)PubMedGoogle Scholar
  7. 7.
    C. Y. C. Pak and L. Arnold, Heterogeneous nucleation of calcium oxalate by seeds of monosodium urate, Proc Soc Exp Biol Med 149: 930 (1975)PubMedGoogle Scholar
  8. 8.
    C. R. Meioni and J. J. Canary, Cystinuria with hyperuricemia, JAMA 200: 169 (1967)Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Toru Shimizu
    • 1
  • Mineko Nishikawa
    • 1
  • Hiroshi Matsushige
    • 1
  1. 1.Gout DivisionKyoto Second Red Cross HospitalKyotoJapan

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