Altered Differential Leukocyte Counts Induced by Acute and Chronic Administration of Trichothecene T-2 Toxin or Aflatoxin B1

  • L. Bruce Weekley
  • Gerald C. Llewellyn


Aflatoxins and trichothecene toxins are produced by some fungal species of Aspergillus and Fusarium when grown on certain substrates which include barley (Hacking et al., 1976), maize (Caldwell and Tuite, 1970), hay (Mirocha et al., 1968), and other agricultural products (Golumbic and Kulik, 1969; Allcroft and Carnaghan, 1961). Cases of mycotoxicoses such as coagulopathies (Bababunmi and Bassir, 1969; John and Miller, 1969; Doerr et al., 1974) and immmunosuppression (Pier and McLoughlin, 1985) have been reported in animals following exposures to both aflatoxin B1 (AFB1) and T-2 toxin. Furthermore, T-2 toxin has been reported to cause anemia, lymphopenia, and eosinopenía concomitant with bone marrow suppression, necrosis of lymphoid tissue, hematopoietic tissue, and rapidly dividing germinal epithelium in the intestinal crypts. Both AFB1 and T-2 toxin have been implicated as biological/chemical warfare agents and may have been components of “yellow rain” repeatedly used in Southeast Asia (Mirocha, 1982; Dashek et al., 1986).


Germinal Epithelium Differential Leukocyte Count Hexose Monophosphate Toxic Change Total Neutrophil 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • L. Bruce Weekley
    • 1
  • Gerald C. Llewellyn
    • 2
  1. 1.School of Veterinary MedicineColorado State UniversityFort CollinsUSA
  2. 2.Bureau of Toxic SubstancesVirginia Department of HealthRichmondUSA

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