Acute Toxicity of Cyclopiazonic Acid in Selected Avian Species
Cyclopiazonic acid (CPA), a toxic indole tetramic acid with a molecular weight of 336.1, was first isolated and identified as a metabolite of Penicillium cyclopium Westling (Holzapfel, 1968). Several species of Penicillium and Aspergillus have been shown to produce CPA, including A. flavus (Dorner, 1983; Dorner et al., 1984; Gallagher et al., 1978; Holzapfel, 1968; Le Bars, 1979; Leistner and Pitt, 1977; Luk et al., 1977; Ohmono et al., 1973). Both peanuts and corn may be naturally contaminated with CPA and aflatoxin Bi (Gallagher et al., 1978; Lansden and Davidson, 1983). P. camemberti Thom, used in the commercial production of cheeses such as Camembert and Brie, was discovered to produce CPA (0.1 to 1.5 µg/g) in the mycelial crust but not in the interior of these cheeses (Le Bars, 1979).
KeywordsCyclopiazonic Acid Broiler Chick Tenuazonic Acid Dose Related Decrease Body Weight Group
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- Cullen, J.M., Wilson, M.E., Hagler, W.M, Jr., Ort, J.F., and Cole, R.J. (1988). Histologic lesions in broiler chicks given cyclopiazonic acid orally. Amer. J. Vet. Res., 49, 728–731.Google Scholar
- Dorner, J.W. (1983). Production of cyclopiazonic acid by Aspergillus tamarii Kita. Appl. Environ. Microbiol., 46, 1435–1437.Google Scholar
- Dorner, J.W., Cole, R.J., Lomax, L.G., Gosser, H.S., and Diener, U.L. (1983). Cyclopiazonic acid production by Aspergillus flavus and its effects on broiler chickens. Appl. Environ. Microbiol., 46, 698–703.Google Scholar
- Lansden, J.A., and Davidson, J.I. (1983). Occurrence of cyclopiazonic acid in peanuts. Appl. Environ. Microbiol., 45, 766–769.Google Scholar
- Le Bars, J. (1979). Cyclopiazonic acid production by Penicillium camemberti Thom and natural occurrence of this mycotoxin in cheese. Appl. Environ. Microbiol., 38, 1052–1055.Google Scholar
- Leistner L. and Pitt, J.I. (1977). Miscellaneous Penicillium toxins, In: Mycotoxins in Human and Animal Health, pp. 549–653 ( C.M. Hesseltine, J.V. Rodricks, and M.A. Mehlman, eds.), Pathotox, Park Forest South,IL.Google Scholar
- Lomax, L.G. and Cole, R.J. (1983). Effects of cyclopiazonic acid on poultry and swine. J. Amer. Vet. Med. Assoc., 188, 349.Google Scholar
- Lomax, L.G., Cole, R.J., and Dorner, J.W. (1984). The toxicity of cyclopiazonic acid in weaned pigs. Vet. Pathol., 21, 418–424.Google Scholar
- Luk, K.C., Kobbe, B., and Townsend, J.M. (1977). Production of cyclopiazonic acid by Aspergillus flavus Link. Appl. Environ. Microbiol., 33, 211–212.Google Scholar
- Nuehring, L.P., Rowland, G.N., Harrison, L.R., Cole, R.J., and Dorner J.W. (1985). Cyclopiazonic acid mycotoxicosis in the dog. Am. J. Vet. Res., 46, 1670–1676.Google Scholar
- Ohmono, S., Sugita, M., and Abe, M. (1973). Isolation of cyclopiazonic acid, cyclopiazonic acid imine and bissecodehydrocyclopiazonic acid from cultures of Aspergillus versicolor (Vuill.) Tiraboshi. J. Agric. Chem. Soc. (Japan), 47, 57–63.Google Scholar
- Rosett, T., Sankhala, R.H., Stickings, C.E., Taylor, M.E.U., and Thomas, R. (1957). Studies in the biochemistry of micro-organisms 103. Metabolites of Alternaria tenuis Auct.: Culture filtrate products. Biochem. J., 67, 390–400.Google Scholar