Acute Toxicity of Cyclopiazonic Acid in Selected Avian Species

  • Mark E. Wilson
  • Winston M. HaglerJr.
  • John M. Cullen
  • Jon F. Ort
  • Richard J. Cole


Cyclopiazonic acid (CPA), a toxic indole tetramic acid with a molecular weight of 336.1, was first isolated and identified as a metabolite of Penicillium cyclopium Westling (Holzapfel, 1968). Several species of Penicillium and Aspergillus have been shown to produce CPA, including A. flavus (Dorner, 1983; Dorner et al., 1984; Gallagher et al., 1978; Holzapfel, 1968; Le Bars, 1979; Leistner and Pitt, 1977; Luk et al., 1977; Ohmono et al., 1973). Both peanuts and corn may be naturally contaminated with CPA and aflatoxin Bi (Gallagher et al., 1978; Lansden and Davidson, 1983). P. camemberti Thom, used in the commercial production of cheeses such as Camembert and Brie, was discovered to produce CPA (0.1 to 1.5 µg/g) in the mycelial crust but not in the interior of these cheeses (Le Bars, 1979).


Cyclopiazonic Acid Broiler Chick Tenuazonic Acid Dose Related Decrease Body Weight Group 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Mark E. Wilson
    • 1
  • Winston M. HaglerJr.
    • 1
  • John M. Cullen
    • 2
  • Jon F. Ort
    • 3
  • Richard J. Cole
    • 4
  1. 1.Department of Poultry Science, Mycotoxin LaboratoryNorth Carolina State UniversityRaleighUSA
  2. 2.Department of Microbiology, Parasitology and PathologyCollege of Veterinary Medicine, North Carolina State UniversityRaleighUSA
  3. 3.Department of Poultry ScienceNorth Carolina State UniversityRaleighUSA
  4. 4.National Peanut Research LaboratoryUSDA/ARSDawsonUSA

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