Extractive Bioconversions in Aqueous Phase Systems
The use of biocatalysts to perform conversions in processes is very appealing in many aspects. The reaction conditions — atmospheric pressure, ambient temperature, water environment and steroselectivity, all favour for biocatalysis. The drawbacks have, however, not been listed frequently, but should, of course, be considered as important. Bioconversions are often slow in relation to chemical processes, they yield a dilute product stream in water, and are often product inhibited. When designing biocatalytic processes, it is thus important to find conditions that fully exploit the advantages offered by the biocatalyst without neglecting the challenges raised by the mentioned limitations.
KeywordsPhase System Bottom Phase Clostridium Acetobutylicum Penicillin Acylase Macromolecular Substrate
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- 3.M. Reslow, P. Adlercreutz and B. Mattiasson, Organic solvents for inorganic synthesis. 2. Influence of log P and water solubility in solvents on enzymatic activity, in: “Biocatalysis in Organic Media,” C. Laane, J. Tramper and M.D. Lilly, eds., Elsevier, Amsterdam (1987)Google Scholar
- 4.H. Nilsson, G. Kjellén, T.G.I. Ling and B. Mattiasson, Reppal-PEX — A new starch derived polymer for applications in aqueous two-phase systems, in: “Proceedings 4th European Congress on Biotechnology,” Vol. 2, O.M. Neijssel, R.R. van der Meer and K. Ch.A.M. Luyben, eds., Elsevier, Amsterdam (1987)Google Scholar
- 6.M. Larsson and B. Mattiasson, Novel process technology for biotechnological solvent production, Chem. Ind. 12:428 (1984)Google Scholar
- 7.B. Mattiasson and M. Larsson, Extractive bioconversions with emphasis on solvent production, in: “Biotechnology and Genetic Engineering Reviews,” Vol. 3, G.E. Russel, ed., Intercept Ltd, Newcastle upon Tyne, UK (1985)Google Scholar
- 10.M. Larsson, V. Arasaratnam and B. Mattiasson, poster presented at 5th Int. Conf. on Partition in Aqueous Two-Phase Systems, Oxford, UK, 23-28 August 1987Google Scholar