An Overview of Theoretical Developments for Protein Partitioning in Aqueous Two-Phase Polymer Systems
Theories of protein partitioning in two-phase systems which account for the effects of different aspects of system composition — such as the choice of materials, protein size, polymer molecular weight, polymer concentration, salt concentration, and affinity ligands — are reviewed. Although the present theories provide some information about specific aspects of partitioning, a comprehensive and fundamental theory which can be used to predict protein partitioning behaviour has not yet been developed. Some recommendations for future work are given.
KeywordsPolymer Concentration Virial Coefficient Polymer Molecular Weight Affinity Ligand System Composition
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