Surface Characterization of Colloidal Drug Carriers for Drug Targeting by Aqueous Two-Phase Partitioning
Surface properties play an important role in the organ distribution of intravenously administered colloidal drug carriers (polymeric particles, parenteral fat emulsions). To avoid the clearance of the particles from the blood stream by the macrophage system of the body, they need to possess surface properties which do not lead to recognition as a foreign particle by the reticuloendothelial system (RES). Carriers with hydrophilic surfaces show a reduced opsonisation in the blood and less clearance by the RES. A hydrophilic surface can be created by coating polymeric particles with polymers or by selecting appropriate emulsifiers for emulsion systems. For the in vitro selection of suitable polymers and emulsifiers, aqueous two-phase partitioning has been employed to characterise the carrier surface.
KeywordsPhoton Correlation Spectroscopy Latex Particle Rose Bengal Photon Correlation Spectroscopy Carrier Surface
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