tRNA Genes - Tinkering in Organization and Expression?
tRNA genes and components of their basic transcription machinery provide well-documented examples for the conservation of cis-acting elements and trans-acting factors from lower to higher eukaryotes. Like other genes that are transcribed by RNA polymerase III, tRNA genes contain intragenic control regions that direct their transcription. For tRNA genes, these highly conserved internal control regions (the A and B boxes) coincide with sequences of the D-loop and the T-loop of the tRNAs (review, Sharp et al., 1985).
KeywordsTransposable Element tRNA Gene Chromatin Organization Template Acti Basic Transcription Machinery
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