Abstract
Three approaches have recently provided new insights into the organization and evolution of the nuclear genomes of vertebrates. They are all based on the compositional properties of genome segments ranging in size from about 1 Kb, for coding sequences, to 100 Kb, for DNA fragments. The rationale for these approaches is the fact that vertebrate genomes are mosaics of isochores, which are evolutionarily relevant structures (see the following paragraph).
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Argos, P., Rossmann, M.G., Grau, U.M., Zuber, A., Franck, G. and Tratschin, J.D., 1979, Thermal stability and protein structure, Biochemistry, 18:5698.
Bernardi, G., 1985, The organization of the vertebrate genome and the problem of the CpG shortage, in: “Biochemistry and Biology of DNA methylation”, G.L. Cantoni and A. Razin, eds., p. 3, Alan Liss, New York.
Bernardi, G. and Bernardi, G., 1985, Codon usage and genome composition, J. Mol. Evol., 22:363.
Bernardi, G., Mouchiroud, D., Gautier, C. and Bernardi, G., 1988, Compositional patterns in vertebrate genomes: conservation and change in evolution, J. Mol. Evol., in press.
Bernardi, G., Olofsson, B., Filipski, J., Zerial, M., Salinas, J., Cuny G., Meunier-Rotival, M. and Rodier, F., 1985, The mosaic genome of warm-blooded vertebrates, Science, 228:953.
Bernardi, G. and Bernardi, G., 1986, Compositional constraints and genome evolution, J. Mol. Evol., 24:1.
Bird, A.P., 1987, CpG islands as gene markers in the vertebrate nucleus, Trends in Genetics, 3:342.
Kimura, M., 1968, Evolutionary rate at the molecular level, Nature, 217:624.
Kimura, M., 1983, The neutral theory of molecular evolution, Cambridge University Press, Cambridge, England.
Medrano, L., Bernardi, G., Couturier, J., Dutrillaux, B. and Bernardi, G., 1988, Chromosome banding and genome compartmentalization in fishes, Chromosoma, 96:178.
Mouchiroud, D., Fichant, G. and Bernardi, G. 1987, Compositional compartmentalization and gene composition in the genomes of vertebrates, J. Mol. Evol., 26:198.
Mouchiroud, D. and Gautier, C., 1988, High codon-usage changes in mammalian genes, Mol. Biol. Evol., 5:192.
Mouchiroud, D., Gautier, C. and Bernardi, G., 1988, The compositionaldistribution of coding sequences and DNA molecules in man and murids, J. Mol. Evol., in press.
Perrin, P. and Bernardi, G. 1987, Directional fixation of mutations in vertebrate evolution, J. Mol. Evol., 26:301.
Salinas, J., Zerial, M., Filipski, J. and Bernardi, G., 1986, Gene distribution and nucleotide sequence organization of the mouse genome, Eur. J. Biochem., 160:469.
Wada, A. and Suyama, A. 1986, Local stability of DNA and RNA secondary structure and its relation to biological function, Prog. Biophys. Mol. Biol., 47:113.
Zerial, M., Salinas, J., Filipski, J. and Bernardi, G., 1986, Gene distribution and nucleotide sequence organization in the human genome, Eur. J. Biochem., 160:479.
Zuckerkandl, E. 1986, Polite DNA: functional density and functional compatibility in genomes, J. Mol. Evol., 24:12.
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© 1989 Plenum Press, New York
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Bernardi, G., Mouchiroud, D., Gautier, C., Bernardi, G. (1989). Compositional Patterns in Vertebrate Genomes: Conservation and Change in Evolution. In: Grunberg-Manago, M., Clark, B.F.C., Zachau, H.G. (eds) Evolutionary Tinkering in Gene Expression. NATO ASI Series, vol 169. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5664-6_13
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DOI: https://doi.org/10.1007/978-1-4684-5664-6_13
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