Blood Flow, Tissue Oxygenation, pH Distribution, and Energy Metabolism of Murine Mammary Adenocarcinomas During Growth
Many solid tumors are relatively resistant to non-surgical therapeutic assaults. A variety of factors are involved in the lack of responsiveness of these neoplasms including cellular heterogeneity due to genetic differences between cells, and physiological factors created by inadequate and heterogeneous vascular networks. Thus, properties such as tumor blood flow, tissue oxygenation, pH distribution and energy metabolism, factors which generally go hand in hand, markedly influence the therapeutic response. Since the strategic approach must consider the physiological microenviron-ment of the cells within a tumor mass and -if possible- should exploit the metabolic micromilieu in designing therapies, we have measured relevant parameters in a well established murine tumor cell line with a known size dependent increase in the radiobiologicaly hypoxic cell fraction.
KeywordsTumor Volume Mammary Tumor Tissue Oxygenation Tumor Blood Flow Murine Mammary Tumor
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