Oxygen Gradients in Two Regions of the Epiphyseal Growth Plate
Although oxygen is required for the continued viability of all cells, controversy exists over oxygen delivery and the extent of vascularization in the cartilage growth plate. The anatomy of this region differs among species and also varies-in different bones in the same species. While previous studies of growth plate metabolism suggest that oxygen gradients exist in the mineralizing region of cartilage and are important to the elongation of the bone during normal growth (Brighton and Heppenstall, 1971), the information necessary to produce a model of growth plate oxygen demands is not available in the literature. Measurements of blood flow to the growth plate have not been reported. Also, the metabolic rates and redox status of chondrocytes are unknown though some work has been initiated in our laboratory (Shapiro et al., 1982,1983;, Silverton et al., 1988).
KeywordsGrowth Plate Hank Balance Salt Solution Hypertrophic Chondrocytes Vascular Channel Oxygen Gradient
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