The Influence of a Temporary Cessation and Reperfusion of Intestinal Blood Flow on the Level of Hepatic Lipid Peroxides

  • J. Lutz
  • A. Augustin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 248)


The liver is an organ with a very high metabolic rate and thereby also a target for the formation and activity of free oxygen radicals. Most substances to be detoxified reach the liver as they progress from the intestinal circulation through the portal vein. During the continued inflow of such substances and by local processes, a certain amount of lipid peroxides is generated under the influence of simultaneously produced free oxygen radicals. Such lipid peroxides react with thiobarbituric acid in the same way as malondialdehyde. Thus the content of lipid peroxides can be expressed in terms of malondialdehyde.


Lipid Peroxide Superior Mesenteric Artery Intestinal Tissue Intestinal Blood Flow Free Oxygen Radical Scavenger 
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  1. Adkison, D., Höllwarth, M.E., Benoit, J.N., Parks, D.A., McCord, J.M. and Granger, D.N. (1986). Role of free radicals in ischemia-reperfusion injury to the liver. Acta Physiol. Scand. Suppl. 548., 101–107.Google Scholar
  2. Augustin, A. and Lutz, J. (1988). The effect of a temporary occlusion of the superior mesenteric artery on the level of lipid peroxides in plasma and intestinal tissue. Pflueg. Arch. 411, R108.Google Scholar
  3. Granger, D.N., Rutili G. and McCord, J.M. (1981). Superoxide radicals in feline intestinal ischemia. Gastroent. 81., 22–29.Google Scholar
  4. Granger, D.N., Höllwarth M.E. and Parks, D.A. (1986). Ischemia-reperfusion injury: role of oxygen-derived free radicals. Acta Physiol. Scand. Suppl. 548, 47–63.Google Scholar
  5. Haglind, E., Haglund, U., Lundgren O. and Schersten, T. (1981). Graded intestinal vascular obstruction. II. Effects of antibiotic pretreatment in the rat. Circulat. Shock 8, 41–47.Google Scholar
  6. Haglund, U. and Lundgren, O. (1972). Reactions within consecutive vascular sections of the small intestine of the cat during prolonged hypotension. Act. Physiol. Scand. 84 151–161.CrossRefGoogle Scholar
  7. Hamar, J., Dezsi, L., Adam, E., Egri, L., Netzer, K.O., Stark, M. and Lutz, J. (1987). Role of fluid replacement, increased oxygen availability by perfluorochemicals and enhanced RES function in the treatment of mesenteric occlusion shock. Res. Exp. Med. 187, 451–459.CrossRefGoogle Scholar
  8. Lutz, J. (1977). Hämodynamik und Sauerstoffversorgung der Leber. In: Experimentelle Hepatologie. (Edit. O. Zelder, M. Fischer and H. Hamelmann). Falck, Freiburg p. 1–14.Google Scholar
  9. Lutz, J., Hamar, J., Netzer, K.O. and Stark, M. (1985). Survival from mesenteric occlusion shock influenced by different treatment in rats. Int. J. Microcirc. Clin. Exp. 4, 103.Google Scholar
  10. Lutz, J. and Schultze, H.G. (1978). Oxygen consumption and oxygen extraction of the feline liver under different types of induced hypoxia. In: Oxygen transport to tissue III (Edit. I.A. Silver, M. Erecinska and H.I. Bicher), Plenum Pub. Corp. N.Y. p. 537–543.Google Scholar
  11. Moorhouse P.C., Grootveld M., Halliwell, B., Quinlan J.G. and Gutteridge. J.M.C. (1987). Allopurinol and oxypurinol are hydroxyl radical scavengers. FEBS letters 213, 23–28.PubMedCrossRefGoogle Scholar
  12. Ohkawa, H., Ohishi, N. and Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochem. 95, 351–358.CrossRefGoogle Scholar
  13. Parks, D.A., Bulkley, G.B., Granger, D.N., Hamilton, S.R. and McCord, J.M. (1982). Ischemic injury in the cat small intestine: role of superoxide radicals. Gastroenterol. 82, 9–15.Google Scholar
  14. Parks, D.A., Shah, A.K. and Granger, D.N. (1984). Oxygen radicals: effects on intestinal vascular permeability. Amer. J. Physiol. 247, G167–G170.PubMedGoogle Scholar
  15. Yagi, K. (1982). Assay for serum lipid peroxide level and its clinical significance. In: Lipid peroxides in biology and medicine. Academic Press Inc. p. 223–242.Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • J. Lutz
    • 1
  • A. Augustin
    • 1
  1. 1.Physiologisches Institut der Universitaet WuerzburgWuerzburgF. R. Germany

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