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Influence of Prostaglandin E1 on Muscular Tissue-PO2 in Patients with Diabetic Gangrene

  • Robert Heinrich
  • Hans-Werner Krawzak
  • Helmut Strosche
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 248)

Abstract

A humid gangrene of the foot is a common complication in patients suffering from diabetes for many years. It is a multicausal disease which combines problems of neuropathy, macro- and especially micro-angiopathy. The surgical activities include vascular reconstruction, sympathectomy (with limited efficacy) and a whole spectrum of local measures. In spite of all therapeutic efforts a major amputation is often unavoidable.

Keywords

Tibialis Anterior Muscle Major Amputation Healthy sUbjects Intraarterial Infusion Severe Peripheral Vascular Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Brecht, T., Ayaz, M., 1985, Circulation parameters during intravenous and intra-arterial administration of increasing doses of prostaglandin Ex in healthy subjects. Klin.Wochenschr., 63:1201PubMedCrossRefGoogle Scholar
  2. Carlson, L.A., Eriksson, I., 1973, Femoral-artery infusion of prostaglandin Ex in severe peripheral vascular disease. Lancet, 1:155PubMedCrossRefGoogle Scholar
  3. Creutzig, A., Lux, M., Alexander, K., 1984, Muscle tissue oxygen pressure fields and transcutaneous oxygen pressure in healthy men during intra-arterial prostaglandin Ex infusion. Inter.Angio., 3 (Suppl.):105Google Scholar
  4. Creutzig, A., Caspary, L., Ranke, C., Klessling, D., Wilkens, J., Fröhlich, J., Alexander, K., 1987, Transcutaner pO2 and Laser Doppler Flux bei steigender Dosierung von intraarteriell und intravenös appliziertem Prostaglandin Ex. VASA, 16:114PubMedGoogle Scholar
  5. Ehrly, A.M., Schenk, J., Saeger-Lorenz, K., 1987, Einfluβ einer intravenösen Gabe von Prostaglandin E1 auf den Muskelgewebesauerstoffdruck, die transkutanen Gasdruck-werte und die Fließeigenschaften des Blutes von Patienten im Stadium III und IV der chronischen arteriellen Verschlußkrankheit. VASA, Suppl. 20: 196Google Scholar
  6. Fleckenstein, W., Heinrich, R., Kersting, T., Schomerus, H., Weiss, C., 1984, A new method for the bedside recording of tissue pO2-histograms. Verh. Dtsch. Ges. Inn. Med., 90:439Google Scholar
  7. Krawzak, H.-W,. Strosche, H., Heinrich, R., 1987, Zum Einfluß systemischer PGB1-Infusion auf den Muskel-pO2 bei Patienten mit arterieller Verschlußkrankheit. Klin.Wochenschr., 65:1004Google Scholar
  8. Krawzak, H.-W., Strosche, H., 1988, Vollständig implantierbare Kathetersysteme zur arteriellen Extremi-täteninfusion. Chirurg, in printGoogle Scholar
  9. Rexroth, W., Amendt, K., Römmele, U., Stein, U., Wagner, E., Hild, R., 1985, Effekte von Prostaglandin E1 auf Hämodynamik und Extremitätenstoffwechsel bei Gesunden und Patienten mit arterieller Verschlußkrankheit Stadium III-IV. VASA, 14:220PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Robert Heinrich
    • 1
  • Hans-Werner Krawzak
    • 2
  • Helmut Strosche
    • 2
  1. 1.Dep. of Medical-GeriatricsRuhr-Universität-Bochum MarienhospitalHerne 1W-Germany
  2. 2.Dep. of SurgeryRuhr-Universität-Bochum MarienhospitalHerne 1W-Germany

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