Hemodynamic Responses to Vasoactive Compounds in Chronically Alcohol Treated Rats

  • H. M. Rhee
  • J. L. Valentine
  • D. Hendrix
  • M. Schweisthal
  • M. Soria
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 248)


Recent evidence suggests that substantial usage of ethanol (hereafter termed alcohol) for a long period of time is positively correlated with hypertension in animal models7 as well as in epidemiologic human investigations5,6,9,12,15,26. Although variables such as smoking, nutritional status, stress and genetic predisposition make human data difficult to interpret, the evidence for the link between substantial amount of alcohol use and high blood pressure is substantial. For example, more than 50% of the alcoholics admitted for detoxification have high blood pressure, and their elevated pressure was returned toward normal when they withdrew the alcohol consumption. However, biochemical or pharmacological mechanisms underlying the positive correlation are poorly understood.2


Chronic Alcohol Liquid Diet Sympathetic Renal Nerve Activity Baroreceptor Sensitivity Vasoactive Compound 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • H. M. Rhee
    • 1
  • J. L. Valentine
    • 1
  • D. Hendrix
    • 1
  • M. Schweisthal
    • 2
  • M. Soria
    • 3
  1. 1.Departments of PharmacologyOral Roberts University School of MedicineTulsaUSA
  2. 2.Departments of AnatomyOral Roberts University School of MedicineTulsaUSA
  3. 3.Departments of PsychiatryOral Roberts University School of MedicineTulsaUSA

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