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Mechanism of Hemoglobin-Induced Spasm in the Isolated Middle Cerebral Artery of the Cat

  • Eors Dora
  • Erzsebet Feher
  • Maria Farago
  • Ildiko Horvath
  • Csaba Szabo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 248)

Abstract

Cerebral vasospasm is frequently associated with subarachnoid hemorrhage. Despite extensive efforts to identify measures to dilate the narrowed arteries, no reliable method exists for preventing or reversing vasospasm(Tanishima, 1980; Wellum et al., 1980: Awad et al., 1987; Nakagomi et al., 1987; Schuier and Ulrich, 1987). One of the major reasons for this inadequacy is the lack of understanding the pathomechanism of vasospasm. Although the cause of vasospasm following subarachnoid hemorrhage is likely to be multifactorial, the present study was focused on the possible involvement of calcium mobilizing vascular smooth muscle receptors and neural mechanisms in the spastic effect of hemoglobin in the middle cerebralartery.

Keywords

Middle Cerebral Artery Mesenteric Artery Subarachnoid Hemorrhage Cerebral Vasospasm Krebs Solution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Eors Dora
    • 1
  • Erzsebet Feher
    • 2
  • Maria Farago
  • Ildiko Horvath
  • Csaba Szabo
  1. 1.Rockville and Exp. Res. Dept. and 2nd Dept. of Physiol.NIAAAUSA
  2. 2.2nd Dept. of AnatomySemmelweis Univ. Med. Sch.BudapestUSA

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