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The Influence of Different Anesthetics on the Oxygen Delivery to and Consumption of the Heart

  • G. J. van Daal
  • B. Lachmann
  • W. Schairer
  • R. Tenbrinck
  • L. J. van Woerkens
  • P. Verdouw
  • W. Erdmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 248)

Abstract

It is well known that some routinely used anesthetics, e.g. halothane, have a severely depressive effect on the cardiovascular system (1,2,3). These depressive effects include: decreased myocardial contractility, decreased systolic as well as diastolic blood pressure as well as a decreased cardiac output. Studies in cell cultures demonstrate, that halothane reduces oxygen consumption and contraction rate of the heart myocyt (4) and affects the uptake and availability of Ca2+ (5,6).

Keywords

Oxygen Delivery Heart Cell Negative Inotropic Effect Halothane Anesthesia Left Atrial Appendage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Sontagg H, Merin RG, Donath H, Radke J, Schenk HD. (1976) Myocardial function and metabolism in the conscious dog and during halothane anesthesia. Anesthesiology.: 51: 204–210.CrossRefGoogle Scholar
  2. 2.
    Merin RG, Kumazawa T, Luka HL. (1979) Myocardial metabolism and oxygenation in man awake and during halothane anesthesia. Anesthesiology.: 44: 402–415.CrossRefGoogle Scholar
  3. 3.
    Merin RG, Verdouw PD, De Jong JW. (1977) Dose-dependent depression of cardiac function and metabolism by halothane in swine (Sus scrofa). Anesthesiology 46: 417–423.PubMedCrossRefGoogle Scholar
  4. 4.
    Albrecht RF, Miletich DJ, Dinsmore P. (1985). Comparative metabolic effects of halothane and enflurane in rat heart cell culture. J. Cardiovasc. Pharmacol: 7: 799–804.PubMedCrossRefGoogle Scholar
  5. 5.
    Komai H, Rusy BF. (1987). Negative inotropic effects of isoflurane and halothane in rabbit papillary muscles. Anesth. Analg.: 66: 29–33.PubMedCrossRefGoogle Scholar
  6. 6.
    Malinconico SM, Hartzeil CR, McCarl RL. (1983). Effect of calcium on halothane-depressed beating in heart cells in culture. Mol. Pharmacol.: 23: 417–423.PubMedGoogle Scholar
  7. 7.
    Saxena PR, Verdouw PD (1985). 5-Carboxamidetryptamine, a compound with high affinity for 5-hydroxytryptamine binding sites, dilates arterioles and constricts arteriovenous anastomoses. Br. J. Pharmac: 84: 533–544.Google Scholar
  8. 8.
    Saxena PR, Schamhardt HC, Forsyth RP, Loeve J. (1980). Computer programs for the radioactive microsphere technique. Determination of regional blood flows and other haemodynamic variables in different experimental circumstances. Comp. Prog. Biomed.: 12: 63–84.CrossRefGoogle Scholar
  9. 9.
    Saxena PR. (1985). An interactive computer programme for data management and parametric and non-parametric statistical analysis. Proc. Br. Pharmacol. Soc: Edinburg: p. D3.Google Scholar
  10. 10.
    Malincino SM, Hartzell CR, McCarl RL. (1983). Effect of calcium on halothane-depressed beating in heart cells in culture. Mol. Pharmacol.: 23: 417–423.Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • G. J. van Daal
    • 1
  • B. Lachmann
    • 1
  • W. Schairer
    • 1
  • R. Tenbrinck
    • 1
  • L. J. van Woerkens
    • 2
  • P. Verdouw
    • 2
  • W. Erdmann
    • 1
  1. 1.Erasmus UniversityRotterdamThe Netherlands
  2. 2.Depts. of Anesthesiology and Experimental CardiologyThorax centreRotterdamThe Netherlands

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