Hypoxia in Saline-Perfused Heart May be Due to Mismatch of Regional Metabolism and Perfusion
A number of observations reported in the literature indicate that the average myocardial tissue oxygen tension is substantially lower than the mean coronary venous oxygen tension. Measurements with small oxygen electrodes done by Schubert et al. (1978) in the saline-perfused cat heart show that large regions have oxygen tensions far below the average venous oxygen tension. Gayeski et al. (1988) found that the saturation of myoglobin with O2 in heart and skeletal muscle indicated a PQ2 of the order of 5 mmHg. Rose et al. (1988) state that there are “two and only two explanations for these anomalies”: diffusional shunting of O2 and a high diffusional resistance for O2 between blood vessel lumen and tissue.
KeywordsOxygen Uptake Rabbit Heart Tissue Oxygen Tension Isolate Rabbit Heart Perfusion Heterogeneity
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