The Effect of Calcium Entry Blocker S-Emopamil on Cerebrocortical Metabolism and Blood Flow Changes Evoked by Graded Hypotension
Calcium is an extremely important intracellular electrolyte which plays a fundamental role in the regulation of many aspects of cell metabolism and activity (Somlyo, 1984; Somlyo et al., 1985; Trump et al., 1984; Siesjo, 1981; Fleckenstein, 1988; Vanhoutte et al., 1988). It has long been known that calcification of tissues is associated with cell death. Regardless of the type of injury, the loss of calcium homeostasis, leads to calcium overload, either by impaired energy metabolism or plasma membrane alterations. This elevated intracellular calcium concentration is responsible for cytoskeletal modifications, the activation of phospholipases which cause perpetuation of membrane damage and finally, mitochondrial calcification.
KeywordsCerebral Blood Flow Arterial Blood Pressure Hemorrhagic Shock Mean Arterial Blood Pressure Calcium Entry Blocker
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