Fractionation of Oxygen Isotopes Due to Equilibration of Oxygen with Hemoglobin
Due to different molecular weights, fractionations occur between the isotopic oxygen molecules 160180 and l602 when passing through the pathways of oxygen transport and metabolism. In man, the rate constant of 1602 uptake was found to be 0.91% above that of the heavier molecule (Schuster and Pflug, 1988). Several constituent processes are known to show higher fractionations. The diffusion rate constant should be greater for 1602 than for 160180 by 3%. Feldman et al. (1959) found for reactions of the respiratory chain that the rate constant of oxidation was higher for 1602 than for 160180 by 1.3%.
KeywordsOxygen Transport Fractionation Effect Oxygen Transfer Rate Pulmonary Capillary Human Hemoglobin
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- Schuster, K.-D., and Pflug, K.P., 1988, The overall fractionation effect of isotopic oxygen molecules during oxygen transport and utilization in humans, submitted for publication in: “Oxygen Transport to Tissue”, XI, K. Rakusan, G.B. Biro, T.K. Goldstick, and Z. Turek, eds., Plenum Publishing Corporation, New York.Google Scholar