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Intrauterine Growth Retardation Related to Maternal Erythrocyte Oxygen Transport

  • Glenn J. B. Mendoza
  • Jaclyn Calem-Grunat
  • Bernard Z. Karmel
  • Michael H. LeBlanc
  • Edwin G. Brown
  • Frank Chervenak
  • Richard W. Krouskop
  • Robert M. Winslow
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 248)

Abstract

Intrauterine growth retardation (IUGR),. is a term applied to fetuses who, at any week of gestation, are undersized for the duration of pregnancy. IUGR is a common problem contributing to 3.5% to 43% of all births (Lin and Evans, 1984). These infants frequently have asphyxia, meconium aspiration, persistent fetal circulation, polycythemia, hypoglycemia and congenital malformations. The causes of IUGR are diverse and can be attributed to maternal, fetal, placental or other unknown factors. Included in the latter group is a subset with inadequate oxygenation whose etiology remains elusive.

Keywords

Intrauterine Growth Retardation Oxygen Dissociation Curve Inadequate Oxygenation Fetal Oxygen Maternal Hemoglobin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ballard, J. L., 1977, Simple assignment of gestational age, Pediatrics, 11:274.Google Scholar
  2. Bauer, C., Ludwig, M., Ludwig, I., Bartels, H., 1969, Factors governing the oxygen affinity of human adult and fetal blood, Respir Physiol, 7:271–277.PubMedCrossRefGoogle Scholar
  3. Brenner, W. E., Edelman, D. A. and Hendricks, C. H., 1976, A standard of fetal growth for the United States of America, Am J Obstet Gyn, 126(5):555.Google Scholar
  4. Forster, H. V., Dempsey, J. A., Thomson, J., et al, 1972, Estimation of arterial PO2, PCO2, pH and lactate from arterialized venous blood, J Appl Physiol, 32(1):134.PubMedGoogle Scholar
  5. Lin, C. C. and Evans, M. I, 1984, “Intrauterine growth retardations pathophysiology and clinical management”, McGraw Hill, New York. Lucius, H., Gahlenbeck, H., Lleine, H. O., et al, 1970, Respiratory functions buffer system and electrolyte concentrations of blood during human pregnancy, Respir Physiol, 9:311.Google Scholar
  6. MacLennan, A. H., Emerson, P. M., Hunter, D. J., et al, 1976, Tissue oxygenation and red cell 2,3-DPG in normal and abnormal pregnancy, Br J Obstet and Gyn, 83:378.CrossRefGoogle Scholar
  7. Madsen, H. and Ditzel, J., 1984, Red cell 2,3-DPG and hemoglobin-oxygen affinity during normal pregnancy, Acta Obstet Scand, 63:399.CrossRefGoogle Scholar
  8. Madsen, H. and Ditzel, J, 1984, Red cell 2,3-DPG and hemoglobin-oxygen affinity during diabetic pregnancy, Acta Obstet Scand, 63:403.CrossRefGoogle Scholar
  9. Moore, L. G., Rounds, S. S., Jahnigen, D., et al, 1982, Infants birth weight is related to maternal arterial oxygenation at high altitude, J Appl Physiol, 52:695.PubMedGoogle Scholar
  10. Morgan, E. J., Baidwan, B., Petty, T. L., et al, 1979, The effects of unanaesthetized arterial puncture on PCO2 and pH, Amer Rev Resp Dis, 120:795.PubMedGoogle Scholar
  11. Rorth, M. and Bill-Brahe, N. E., 1971, 2,3-DPG and creatine in the red cell during human pregnancy, Scand J Clin Lab Invest, 28, 271.PubMedCrossRefGoogle Scholar
  12. Sacks, L. M. and Delivoria-Papadopouos, M., 1984, Hemoglobin-oxygen interactions, Semin Perinatol, 8(3) 168.PubMedGoogle Scholar
  13. Samaja, M., Mosca, A., Luzzana, M., et al, 1981, Equations and nomogram for the relationship of human blood P50 with 2,3-DPG, CO2 and H+, Clin. Chem, 27:1856.PubMedGoogle Scholar
  14. Soothill, P. W. and Nicolaides, K. H., 1987, Blood gases and blood flow in IUGR pregnancies. Soc of Perinatal Obstet, 7th Annual Mtg, (Unpublished commiunication).Google Scholar
  15. Tsai, C. H. and Leeuw, N. K., 1982, Changes in 2,3-DPG during pregnancy and Puerperium in normal women and in B-Thalassemia heterozygous women, Am J Obstet Gyn, 142:520.Google Scholar
  16. Weiss, R. R., Roginsky, M. S., Meiner, A., et al, 1976, Erythrocyte 2,3-DPG in normal and hypertensive gravid women and their newborn infants, Am J Obstet Gyn, 124(7):692.Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Glenn J. B. Mendoza
    • 1
  • Jaclyn Calem-Grunat
    • 2
  • Bernard Z. Karmel
    • 2
  • Michael H. LeBlanc
    • 3
  • Edwin G. Brown
    • 3
  • Frank Chervenak
    • 4
  • Richard W. Krouskop
    • 5
  • Robert M. Winslow
    • 6
  1. 1.Department of PediatricsBeth Israel Medical CenterNew YorkUSA
  2. 2.Department of PediatricsMt. Sinai Medical CenterNew YorkUSA
  3. 3.Department of PediatricsUniversity of Mississippi Medical CenterJacksonUSA
  4. 4.Department of Maternal-Fetal MedicineCornell Medical Center-NY HospitalNew YorkUSA
  5. 5.Department of PediatricsLSU Medical CenterShreveportUSA
  6. 6.Division of Blood Research Letterman Army Institute of ResearchSan FranciscoUSA

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