Myocardial Oxygen Transport During Leftward Shifts of the Oxygen Dissociation Curve by Carbamylation or Hypothermia
The heart is a highly aerobic organ whose ability to adjust to shifts in the O2 dissociation curve is of considerable interest (Harkin, 1977). For example, hypothermia is known to increase hemoglobin O2 affinity and is often used by surgeons in conjunction with other forms of cardioplegia during cardiac surgery (Hearse, 1981). In evaluating the usefulness of hypothermia for myocardial protection it is important to understand how the coronary circulation adapts to the potential ill effects of an increase in hemoglobin-O2 affinity.
KeywordsPerfusion Pressure Coronary Sinus Coronary Flow Myocardial Oxygen Consumption Left Ventricular Systolic Pressure
Unable to display preview. Download preview PDF.
- Baer, R. W., 1987, Myocardial oxygenation after increasing oxyhemoglobin affinity by carbamylation. Fed. Proc. 46: 1113 (Abstr.).Google Scholar
- Cerami, A., Allen, T.A., Graziano, J. H., DeFuria, F. G., Manning, J. M., and Gillete, P. N., 1973, Pharmacology of Cyanate. I. General effects on experimental animals. J. Pharm. Exper. Ther. 185: 653–666.Google Scholar
- Duvelleroy, M. A., Martin, J. L., Teisseire, B., Gauduel, Y., and Durable, M., 1980, Abnormal hemoglobin oxygen affinity and the coronary circulation. Biblthca. Haemat. 46: 70–77.Google Scholar
- Harkin, A. H., 1977, The surgical significance of the oxyhemoglobin dissociation curve. Surg. Gyn. Obst. 144: 935–955.Google Scholar
- Hearse, D. J., Braimbridge, M. V., and Jynge, P., 1981, Protection of the ischemic myocardium: cardioplegia. Raven Press. New York. pp 167–208.Google Scholar
- Honig, C. R. and Gayeski, T. E. J., 1987, Comparison of intracellular PO2 and conditions for blood-tissue transport in heart and working red skeletal muscle. Adv. Exper. Med. Biol. 215: 309–321.Google Scholar
- Ross, B. K., and Hlastala, M. P., 1981, Increased hemoglobin oxygen affinity does not decrease skeletal muscle oxygen consumption. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 51: 864–870.Google Scholar
- Woodson, R. D., 1988, Evidence that changes in blood oxygen affinity modulate oxygen delivery: implications for control of tissue Po2 gradients. Adv. Exper. Med. Biol. 222: 309–313.Google Scholar
- Woodson, R. D., and Auerbach, S., 1982, Effect of increased oxygen affinity and anemia on cardiac output and its distribution. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 53: 1299–1306.Google Scholar