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Myocardial Oxygen Transport During Leftward Shifts of the Oxygen Dissociation Curve by Carbamylation or Hypothermia

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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 248)

Abstract

The heart is a highly aerobic organ whose ability to adjust to shifts in the O2 dissociation curve is of considerable interest (Harkin, 1977). For example, hypothermia is known to increase hemoglobin O2 affinity and is often used by surgeons in conjunction with other forms of cardioplegia during cardiac surgery (Hearse, 1981). In evaluating the usefulness of hypothermia for myocardial protection it is important to understand how the coronary circulation adapts to the potential ill effects of an increase in hemoglobin-O2 affinity.

Keywords

Perfusion Pressure Coronary Sinus Coronary Flow Myocardial Oxygen Consumption Left Ventricular Systolic Pressure 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  1. 1.Kirksville College of Osteopathic MedicineKirksvilleUSA

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