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Multicomponent Analysis of Near-Infrared Spectra of Anesthetized Rat Head: (I) Estimation of Component Spectra by Principal Component Analysis

  • Ryuichiro Araki
  • Ichiro Nashimoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 248)

Abstract

Near-infrared (NIR) spectrophotometry has been proposed for continuous and noninvasive monitoring of Hb oxygenation (So2) and redox state of cyt. aa3 in living tissues (Jöbsis, 1977 and others). In the previous articles, however, it has been assumed that only Hb and cyt. aa3 contribute to changes in NIR spectra of the tissues. Since various biological materials exist in the living organs, spectral changes of the other kinds of biological chromophores may be involved in the changes in NIR spectra of the tissues. We attempted to establish a method for quantitating near-infrared spectra of anesthetized rat head using multiple regression analysis of the spectral data which is so-called the ‘curve-fitting technique’ (Araki and Nashimoto, this volume). However, the number and standard spectral curves of ingredients of the mixtures must be already known to establish quantitative analysis by this technique (Leggett, 1977).

Keywords

Principal Component Analysis Methyl Orange Data Spectrum Acute Hypoxia Component Spectrum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Araki R., Nashimoto I., and Takano T., 1988, The effect of hyperbaric oxygen on cerebral hemoglobin oxygenation and dissociation rate of carboxyhemoglobin in anesthetized rats: Spectroscopic approach, Adv. Exp. Med. Biol., 222:375–381.PubMedGoogle Scholar
  2. Jöbsis F. F., 1977, Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters, Science, 198:1264–1267.PubMedCrossRefGoogle Scholar
  3. Leggett D. J., Numerical Analysis of Multicomponent Spectra, 1977, Anal. Chem., 49:276–281.CrossRefGoogle Scholar
  4. Sasaki K., Kawata S., and Minami S., 1983, Constrained Nonlinear Method for Estimating Component Spectra from Multicomponent Mixtures, Appl. Opt., 22:3599–3603.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Ryuichiro Araki
    • 1
  • Ichiro Nashimoto
    • 1
  1. 1.Department of HygieneSaitama Medical SchoolIruma-gun, SaitamaJapan

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