Mechanical Analysis of Hair Cell Microstructure and Motility

  • C. R. Steele
  • D. H. Jen
Part of the NATO ASI Series book series (NSSA)


In the past few years, a number of important discoveries have been made which deal with the microstructure of the cochlea and the possible relation with the active process in the normal function. The purpose of this paper is to summarize some considerations on the mechanical interpretation of these discoveries. Specifically, the implications of the tip and lateral fibers connecting the cilia on the inner and outer hair cells, and the motility of the outer hair cells is treated.


Hair Cell Outer Hair Cell Basilar Membrane Hair Bundle Fiber Angle 
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  1. Ashmore, J.F. (1987) A fast motile response in guinea-pig outer hair cells: the cellular basis of the cochlear amplifier. J. Physiol., 388, 323–347.PubMedGoogle Scholar
  2. Ashmore, J.F., and Brownell, W.E. (1986) Kilohertz movements induced by electrical stimulation in outer hair cells isolated from the guinea pig cochlea. J. Physiol., P41.Google Scholar
  3. Brownell, W.E., and Kacher, B. (1985) Outer hair cell motility: a possible electrokinetic mechanism. In: Peripheral Auditory Mechanisms (Eds: Allen, J.B., Hubbard, A.E., Neely, S.T. and Tubis, A.) Springer, Berlin, pp. 369–376.Google Scholar
  4. Crane, H.D. (1982) IHC-TM connect-disconnect and efferent control V. J. Acoust. Soc. Am. 72, 93–101.PubMedCrossRefGoogle Scholar
  5. Flock, Å, Flock, B., and Ulfendahl, M. (1986) Mechanisms of movement in outer hair cells and a possible structural basis. Arch. Oto-Rhino-Laryngol., 242, 83–90.CrossRefGoogle Scholar
  6. Flock, A. (1986) Mechanical properties of hair cells. Hearing Research 22, 80.CrossRefGoogle Scholar
  7. Flock, A. and Strelioff, D. (1986) Studies on hair cells in isolated coils from the guinea pig cochlea. Hearing Research 15, 11–18.Google Scholar
  8. Furness, D.N., and Hackney, C.M. (1985) Cross-links between stereocilia in the guinea pig cochlea. Hearing Research 18, 177–188.PubMedCrossRefGoogle Scholar
  9. Furness, D.N., Hackney, C.M., and Evans, E.F. (1986) The ultrastructure of stereociliary cross-links. Hearing Research 22, 79.CrossRefGoogle Scholar
  10. Holley, M.C., and Ashmore, J.F., (1988) On the mechanism of a high-frequency force generator in outer hair cells isolated from the guinea pig cochlea. Proc. R. Soc. Lond. B 232, 413–429.PubMedCrossRefGoogle Scholar
  11. Holmes, M.H., and Bell, J. (1985) A model for transduction in hair cells involving strainactivated conductance. In: Peripheral Auditory Mechanisms (Eds: Allen, J.B., Hubbard, A.E., Neely, S.T. and Tubis, A.) Springer, Berlin, pp. 385–393.Google Scholar
  12. Jen, D.H., and Steele, C. R. (1987) Electrokinetic model of cochlear hair cell motility. J. Acoust. Soc. Am. 82, 1667–1678.PubMedCrossRefGoogle Scholar
  13. Lim, D.J. (1980) Cochlear anatomy related to cochlear micromechanics. A review. J. Acoust. Soc. Am. 67, 1686–1695.CrossRefGoogle Scholar
  14. Lim, D.J. (1986) Functional structure of the organ of Corti: a review. Hearing Research 22, 117–146.PubMedCrossRefGoogle Scholar
  15. Miller, C.E. (1985) Structural implications of basilar membrane compliance measurements. J. Acoust. Soc. Am. 77, 1465–1474.PubMedCrossRefGoogle Scholar
  16. Pickles, J.O., Comis, S.D., and Osborne, M.P. (1984) Cross-links between stereocilia in the guinea pig organ of Corti, and their possible relation to sensory transduction. Hearing Research 15, 103–112.PubMedCrossRefGoogle Scholar
  17. Pickles, J.O., Osborne, M.P., and Comis, S.D. (1987) Vulnerability of tip links between stereocilia to acoustic trauma in the guinea pig. Hearing Research 25, 173–183.PubMedCrossRefGoogle Scholar
  18. Raftenberg, M.N. (1985) A model for cochlear micromechanics. Ph.D. Thesis, Johns Hopkins University.Google Scholar
  19. Strelioff, D. and Flock, A. (1986) Stiffness of sensory-cell hair bundles in the isolated guinea pig cochlea. Hearing Research 15, 19–28.CrossRefGoogle Scholar
  20. Terakawa, S., (1985) Potential-dependent variations of the intracellular pressure in the intracellularly perfused squid giant axon. J.Physiol., Lond. 369, 229–248.PubMedGoogle Scholar
  21. Wainwright, S.A., Biggs, W.D., Currey, J.D., and Gosline, J.M. (1976) Mechanical Designs in Organisms (John Wiley, New York).Google Scholar
  22. Zenner, H.P., Zimmermann, U., and Gitter, A.H., (1987) Fast motility of isolated auditory sensory cells. Biochem. and Biophysic. Res. Comm. 149, 304–308.CrossRefGoogle Scholar
  23. Howard, J. and Ashmore, J.F. (1986) Stiffness of sensory hair bundles in the sacculus of the frog. Hearing Res. 23, 93–104.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • C. R. Steele
    • 1
  • D. H. Jen
    • 1
    • 2
  1. 1.Division of Applied Mechanics, Durand BuildingStanford UniversityStanfordUSA
  2. 2.General Products DivisionIBMSan JoseUSA

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