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Tip-Link Organization in Relation to the Structure and Orientation of Stereovillar Bundles

  • J. O. Pickles
  • M. P. Osborne
  • S. D. Comis
  • C. Köppl
  • O. Gleich
  • J. Brix
  • G. A. Manley
Part of the NATO ASI Series book series (NSSA)

Abstract

The linkages between stereovilli (stereocilia) of hair cells have been implicated both in the mechanical properties of the bundles and in the transmission of stimulus-induced movements to the individual mechanotransducer channels (e.g. Flock and Strelioff, 1984; Pickles et al., 1984; Hudspeth, 1985). Here, we describe new observations on the fine structure of the tip links between stereovilli. We also show that the spatial organization of the tip links in bundles of different conformations in a variety of species is appropriate for a role in transduction.

Keywords

Hair Cell Actin Filament Outer Hair Cell Bilateral Symmetry Hair Bundle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • J. O. Pickles
    • 1
  • M. P. Osborne
    • 1
  • S. D. Comis
    • 1
  • C. Köppl
    • 1
    • 2
  • O. Gleich
    • 1
    • 2
  • J. Brix
    • 1
    • 2
  • G. A. Manley
    • 1
    • 2
  1. 1.Department of PhysiologyUniversity of BirminghamBirminghamUK
  2. 2.Institut für ZoologieTechnische Universität MünchenMünchenFDR

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