Nonlinear Interactions in the Mechanical Response of the Cochlea to Two-Tone Stimuli

  • Luis Robles
  • Mario A. Ruggero
  • Nola C. Rich
Part of the NATO ASI Series book series (NSSA)


The reduction of the auditory response to one tone due to the simultaneous presence of a second tone is known as two-tone suppression. This nonlinear cochlear response was first described by Galambos and Davis (1944) in electrophysiological recordings from the cat auditory nerve. Since then two-tone suppression has been extensively studied in cochlear afferents of mammals (Nomoto et al., 1964; Kiang et al., 1965; Hind et al., 1967; Sachs and Kiang, 1968) and also of amphibia (Frischkopf and Goldstein, 1963; Feng et al., 1975), birds (Sachs et al., 1974) and reptiles (Holton and Weiss, 1978). Two-tone suppression seems to be demonstrable in all well-studied cochlear fibers, for suppressors at frequencies on both sides of the tuning curve (Sachs and Kiang, 1968; Sachs, 1969; Abbas and Sachs, 1976), and has also been observed in guinea pig inner hair cells (Sellick and Russell, 1979).


Hair Cell Auditory Nerve Squirrel Monkey Basilar Membrane Tuning Curve 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Luis Robles
    • 1
  • Mario A. Ruggero
    • 1
    • 2
  • Nola C. Rich
    • 1
    • 2
  1. 1.Departamento de Fisiología y Biofísica, Facultad de MedicinaUniversidad de ChileCasillaChile
  2. 2.Department of OtolaryngologyUniversity of MinnesotaMinneapolisUSA

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