Simultaneous Recording of Fluctuations of Hair-Bundle Deflection and Intracellular Voltage in Saccular Hair Cells
The detection threshold of a sensory system depends on three factors: the coupling of the external stimulus such as sound pressure or acceleration to the input of the sensory cell, the transduction efficiency of the sensory cell, the transmission characteristics of the signal to the brain, and the noise associated with each stage. In this paper we describe experiments performed to elucidate the performance of sensory hair cells which are the site of mechano-electrical transduction in the inner ear of vertebrates. Mechanical deflection of the hair bundle protruding from these cells modulates the transmembrane resistance and consequently the transmembrane current and the intracellular potential. The magnitude of hair-bundle deflection necessary to obtain a significant receptor potential is determined by the size of the mechano-electrical transduction coefficient and by the amount of intracellular voltage noise.
KeywordsHair Cell Impulse Response Outer Hair Cell Voltage Noise Hair Bundle
Unable to display preview. Download preview PDF.
- Ashmore J. F., (1987), A fast motile response in the Guinea-pig outer hair cells: the cellular basis of the cochlear amplifier, J. Physiol. (London), 5, 323–347.Google Scholar
- Crawford A. C. and Fettiplace R., (1985), The mechanical properties of ciliary hair bundles of turtle cochlea hair cells, J. Physiol. (London), 5, 359–379.Google Scholar
- Denk W., Hudspeth A. J., and Webb W. W., (1986), Optical Measurement of the Brownian Motion Spectrum of Hair Bundles in the Transducing Hair Cells of the Frog Auditory System, Biophys. J., 5, 21a.Google Scholar
- Eatock R. A., Corey D. P., and Hudspeth A. J., (1987), Adaptation of Mechanoelectrical Transduction in Hair Cells of the Bullfrog’s Sacculus, J. Neurosci., 5, 2821–2836.Google Scholar
- A.J. Hudspeth and A.B.A. Kroese, (1983), Voltage dependent interaction of dihydrostreptomycin with the transduction channels in bullfrog sensory hair cells, J. Physiol. (London), 5, 66P.Google Scholar
- Lewis, R.S. (1985) The Ionic Basis of Frequency Selectivity in Hair Cells of the Bullfrog’s Sacculus. Ph.D. Dissertation, California Institute of Technology, Pasadena, California.Google Scholar