Large Bowel Tumor Promotion by Diamine Oxidase Inhibition: Animal Model and Clinical Aspects

  • Jürgen Kusche
  • Rudolf Menningen
  • Lothar Leisten
  • Bernhard Krakamp
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 250)


In the intestinal mucosa, diamine oxidase probably is involved in a feedback regulation mechanism for the termination of proliferation. This was proven by a considerable promotion of large bowel tumors induced by diamine oxidase inhibition in a rat model. Carcinogenesis was accompanied by characteristic alterations in mucosal diamine oxidase activity. In large bowel cancer patients similar changes in intestinal diamine oxidase activity had been observed as in the animal model. Conclusion: Events entailing a reduction of diamine oxidase activity are suspicious for large bowel cancer promotion under experimental and clinical conditions.


Intestinal Mucosa Large Bowel Diamine Oxidase Polyamine Metabolism Large Bowel Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    J. Sattler, and W. Lorenz, Food inducted histaminosis as an epidemio-logical problem: plasma histamine elevation and haemodynamic alterations after oral histamine administration and blockade of diamine oxidase (DAO). Agents Actions 23: 361–365 (1988).PubMedCrossRefGoogle Scholar
  2. 2.
    J. Kusche, W. Lorenz, C.-D. Stahlknecht, H. Richter, R. Hesterberg, A. Schmal, E. Hinterlang, D. Weber, and C. Ohmann, Intestinal diamine oxidase and histamine release in rabbit mesenteric ischemia, Gastroenterology 80: 980–987 (1981).PubMedGoogle Scholar
  3. 3.
    J. Kusche and W. Lorenz, Diamine oxidase, in: “Methods of enzymatic analysis”, H.U. Bergmeyer ed., Verlag Chemie, Weinheim (1983).Google Scholar
  4. 4.
    A. P. Maskens, Mechanism of colorectal carcinogenesis in animal models: possible implications in cancer prevention, in: Precan-cerous lesions of the gastrointestinal tract, P. Sherlock, B.C.(1983).Google Scholar
  5. 5.
    J. Kusche, J.R. Izbicki, R. Menningen, A. Curt, and J. V. Parkin, The effect of experimental carcinogenesis on intestinal diamine oxidase, a polyamine deaminating enzyme, Cancer Prev.Detect. 9: 17–29 (1986).Google Scholar
  6. 6.
    J. Kusche, R. Menningen, and L. Leisten, Early alterations of rat intestinal diamine oxidase activity by azoxymethane, an intestinal carcinogen. Agents Actions (in press) (1989).Google Scholar
  7. 7.
    R. Menningen J. Kusche L. Leisten and K. Erpenbach Diamine oxidase DAO activity and intestinal mucosa integrity influence of suture techniques Agents Actions 20 277–280 1987CrossRefGoogle Scholar
  8. 8.
    R. Menningen, J. Kusche, and K. Erpenbach, Adaptive response of the rat small bowel to 70% resection: is the intestinal diamine oxidase involved in mucosal growth regulation?, Biogenic Amines 5: 55–68 (1987).Google Scholar
  9. 9.
    G. D. Luk, S.R. Hamilton, D. O’Ceallaigh, J. Smith, E. Natuzzi, and S. B. Baylin, Azoxymethane (AMO) induces a generalized biphasic increase in intestinal ornithine decarboxylase (ODC) during colon carcinogenesis, Gastroenterology 82: 1121 (1982).Google Scholar
  10. 10.
    R. Menningen, M. Günther, M. Bönninghoff, C.-D. Stahlknecht, I. Kubitza, and J. Kusche, Diamine oxidase as a marker of intestinal integrity in acute appendicitis, Agents Actions 18: 38–40 (1986).PubMedCrossRefGoogle Scholar
  11. 11.
    L. Vio, and M. G. Mamolo, Potential antihypertensive agents IV-Amino-guanidine and hydrazinopyrinidine derivatives, II Farmaco 38: 255–264 (1983).Google Scholar
  12. 12.
    M. Brownlec, H. Vlassara, A. Kooney, P. Ulrich, and A. Cerami, Amino-guanidine prevents diabetes induced arterial wall protein cross-linking, Science 232: 1629–1632 (1986).CrossRefGoogle Scholar
  13. 13.
    S. B. Baylin, Z. Horakova, and M. A. Beaven, Increased food consumption and growth after treatment with aminoguanidine, Experientia 31: 562–562 (1975).PubMedCrossRefGoogle Scholar
  14. 14.
    J. Kusche, W. Lorenz, C.-D. Stahlknecht, A. Friedrich, K. Boo, and G. Reichert, Diamine oxidase activity in gastric and duodenal mucosa of man and other mammals with special reference to the pyloric junction, Agents Actions 8: 366–371 (1978).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Jürgen Kusche
    • 1
  • Rudolf Menningen
    • 1
  • Lothar Leisten
    • 1
  • Bernhard Krakamp
    • 2
  1. 1.IInd Department of SurgeryUniversity of CologneGermany
  2. 2.Ist Medical ClinicKöln-MerheimGermany

Personalised recommendations