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Large Bowel Tumor Promotion by Diamine Oxidase Inhibition: Animal Model and Clinical Aspects

  • Jürgen Kusche
  • Rudolf Menningen
  • Lothar Leisten
  • Bernhard Krakamp
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 250)

Abstract

In the intestinal mucosa, diamine oxidase probably is involved in a feedback regulation mechanism for the termination of proliferation. This was proven by a considerable promotion of large bowel tumors induced by diamine oxidase inhibition in a rat model. Carcinogenesis was accompanied by characteristic alterations in mucosal diamine oxidase activity. In large bowel cancer patients similar changes in intestinal diamine oxidase activity had been observed as in the animal model. Conclusion: Events entailing a reduction of diamine oxidase activity are suspicious for large bowel cancer promotion under experimental and clinical conditions.

Keywords

Intestinal Mucosa Large Bowel Diamine Oxidase Polyamine Metabolism Large Bowel Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Jürgen Kusche
    • 1
  • Rudolf Menningen
    • 1
  • Lothar Leisten
    • 1
  • Bernhard Krakamp
    • 2
  1. 1.IInd Department of SurgeryUniversity of CologneGermany
  2. 2.Ist Medical ClinicKöln-MerheimGermany

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