The Effects of Polyamine Analogues on Malaria Parasites In Vitro and In Vivo

  • Alan J. Bitonti
  • Peter P. McCann
  • Albert Sjoerdsma
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 250)


Malaria remains one of the most important human infectious diseases in the world. Resistance of Plasmodium falciparum to chloroquine and other antimalarial drugs has created an urgent need for new drugs which are effective against resistant strains (1). Radical departure from the chemical classes of compounds effective in the past is needed to circumvent the problems of cross-resistance between drugs. We have studied a new approach to the chemotherapy of malaria which involves the disruption of the biosynthesis and/or intracellular function of the polyamines, putrescine, spermidine and spermine.


Plasmodium Falciparum Antimalarial Drug Ornithine Decarboxylase Antimalarial Activity Total Nucleic Acid 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Alan J. Bitonti
    • 1
  • Peter P. McCann
    • 1
  • Albert Sjoerdsma
    • 1
  1. 1.Merrell Dow Research InstituteCincinnatiUSA

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