The Effects of Polyamine Analogues on Malaria Parasites In Vitro and In Vivo
Malaria remains one of the most important human infectious diseases in the world. Resistance of Plasmodium falciparum to chloroquine and other antimalarial drugs has created an urgent need for new drugs which are effective against resistant strains (1). Radical departure from the chemical classes of compounds effective in the past is needed to circumvent the problems of cross-resistance between drugs. We have studied a new approach to the chemotherapy of malaria which involves the disruption of the biosynthesis and/or intracellular function of the polyamines, putrescine, spermidine and spermine.
KeywordsPlasmodium Falciparum Antimalarial Drug Ornithine Decarboxylase Antimalarial Activity Total Nucleic Acid
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- 2.A. E. Pegg, P. P. McCann, Polyamine Metabolism and function. Am. J. Physiol. 234, C212–C221 (1982).Google Scholar
- 3.P. P. McCann, C. J. Bacchi, W. L. Hanson, G. D. Cain, H. C. Nathan, S. H. Hutner, and A. Sjoerdsma, Effect on Parasitic Protozoa of α-Difluoromethylornithine — An Inhibitor of Ornithine Decarboxylase. Adv. Polyamine Res. 3, 97–110 (1981).Google Scholar
- 4.J. M. Whaun and N. D. Brown, Ornithine Decarboxylase Inhibition and the Malaria-Infected Red Cell: A Model for Polyamine Metabolism and Growth. J. Pharm. Exp. Ther. 233, 507–511 (1985).Google Scholar
- 6.C. W. Porter and J. R. Sufrin, Interference with Polyamine Biosynthesis and/or Function by Analogs of Polyamines or Methionine as a Potential Anticancer Chemotherapeutic Strategy.Google Scholar
- 22.Y. G. Assaraf, J. Golenser, D. T. Spira and U. Bachrach, Synchronization of P. falciparum Cultures by DL-α-Difluoromethylornithine and Putrescine. J. Protozool. 31, A78–A79 (1984).Google Scholar