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Progress in Polyamine Research pp 707–716Cite as

Mechanism of Antitumor Activity of Norspermidine, a Structural Homologue of Spermidine

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 250))

Abstract

The availability of α-difluoromethylornithine (DFMO), a specific and irreversible inhibitor of ornithine decarboxylase (ODC) made it possible to demonstrate an essential role for polyamines in cell proliferation and differentiation.1, 2, 3 Polyamine depletion induced by DFMO treatment in a number of in vitro and in vivo model systems resulted in growth retardation4, 5, 6 and cell death.7, 8 Further, the remarkable low toxicity of DFMO and its significant antitumor and antimetastatic activity in experimental tumor models7, 10, 11 suggested that approaches aimed at perturbing polyamine metabolism should be explored in identifying novel antitumor agents.

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Authors and Affiliations

  1. Merrell Dow Research Institute, 2110 E. Galbraith Road, Cincinnati, Ohio, 45215, USA

    Prasad S. Sunkara, John H. Zwolshen, Nellikunja J. Prakash & Terry L. Bowlin

Authors
  1. Prasad S. Sunkara
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  2. John H. Zwolshen
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  3. Nellikunja J. Prakash
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  4. Terry L. Bowlin
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Editor information

Editors and Affiliations

  1. Institute of Biochemistry of Macromolecules, University of Naples, Naples, Italy

    Vincenzo Zappia

  2. The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA

    Anthony E. Pegg

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© 1988 Plenum Press, New York

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Sunkara, P.S., Zwolshen, J.H., Prakash, N.J., Bowlin, T.L. (1988). Mechanism of Antitumor Activity of Norspermidine, a Structural Homologue of Spermidine. In: Zappia, V., Pegg, A.E. (eds) Progress in Polyamine Research. Advances in Experimental Medicine and Biology, vol 250. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5637-0_62

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  • DOI: https://doi.org/10.1007/978-1-4684-5637-0_62

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5639-4

  • Online ISBN: 978-1-4684-5637-0

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