The Role of Glutathionylspermidine and Trypanothione in Regulation of Intracellular Spermidine Levels During Growth of Crithidia Fasciculata

  • Alan H. Fairlamb
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 250)


Trypanosomatids are unusual in that a considerable proportion of their intracellular spermidine and glutathione (GSH) is found as the conjugate Ni-glutathionylspermidine (GSH-SPD) and N1-, N8-bis-(glutathionyl)spermidine (T[SH]2)1. The latter compound is unique to the parasitic and free-living Trypanosomatidae and has been assigned the trivial name trypano-thione2.


Glutathione Reductase Ornithine Decarboxylase Stationary Phase Cell Bloodstream Form Buthionine Sulfoximine 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Alan H. Fairlamb
    • 1
  1. 1.Department of Medical ProtozoologyLondon School of Hygiene and Tropical MedicineLondonUK

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