Ornithine Decarboxylase Antizyme in Mammalian Tissues
Antizyme was first described by Canellakis and coworkers (1) as a protein inhibitor of ornithine decarboxylase which is induced in response to an elevated level of putrescine in cells in culture or in liver of rats treated with putrescine. It was characterized as protease-sensitive, nuclease- insensitive and heat-labile, while the inhibition is concentration-dependent, time-independent and non-competitive with respect to ornithine (1).
KeywordsMammary Gland Ornithine Decarboxylase Modifier Protein Ornithine Decarboxylase Activity Diamino Propane
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