Ornithine Decarboxylase Antizyme in Mammalian Tissues

  • Margaret E. Brosnan
  • Yu-Wan Hu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 250)


Antizyme was first described by Canellakis and coworkers (1) as a protein inhibitor of ornithine decarboxylase which is induced in response to an elevated level of putrescine in cells in culture or in liver of rats treated with putrescine. It was characterized as protease-sensitive, nuclease- insensitive and heat-labile, while the inhibition is concentration-dependent, time-independent and non-competitive with respect to ornithine (1).


Mammary Gland Ornithine Decarboxylase Modifier Protein Ornithine Decarboxylase Activity Diamino Propane 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Margaret E. Brosnan
    • 1
  • Yu-Wan Hu
    • 1
  1. 1.Department of BiochemistryMemorial University of NewfoundlandSt. John’sCanada

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