Abnormalities of Polyamine Biosynthesis in Spinal Cord of Totally Gastrectomized Rats
Hematological and neurological sequelae are the two major manifestations in man of Addisonian pernicious anemia (PA)1. The degree of central nervous system (CNS) damage is not always well correlated with the severity of the anemia and therefore, the neurological disease in PA is not secondary to the anemia2. The neurological illness in PA chiefly affects the white matter of the dorsal and lateral columns of the spinal cord (SC) in man and can be reproduced experimentally in other mammals3, 4. It is generally considered that the major neuropathological feature in PA is an uneven and severe “demyelination” (spongiform degeneration)3, 4 of SC. The first full description of this demyelinating neuropathy was given by Russell, Batten and Collier5 at the beginning of this century, who named it “subacute combined degeneration” (SCD) of the SC. This term, however, fails to encompass all aspects of the disease, because it does not clearly suggest involvement of peripheral nerves and brain. Although since then many other terms for this neurological disorder have been tentatively introduced, the initial term, i. e., SCD, is generally widely used by most authors and will be used here by us.
KeywordsTotal Gastrectomy Pernicious Anemia Polyamine Biosynthesis Subacute Combine Degeneration Rousettus Aegyptiacus
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