Regulation of Protein Synthesis by Polyamines
Polyamines have been implicated in numerous growth processes (1, 2). Since polyamines are cationic, they probably participate in many cellular processes through their binding to DNA, RNA, and phospholipids (3). The stimulatory influence of polyamines on some kinds of protein synthesis has been established from in vitro experiments with both Escherichia coli and eukaryotic cell-free systems (4–7) and from in vivo experiments with E. coli polyamine-requiring mutants and bovine polyamine-deficient lymphocytes (8–11). Findings from these latter studies indicate that an important in vivo function of polyamines is to stimulate the synthesis of specific proteins, such as the polyamine-induced protein of E. coli (9) and thymidine kinase of bovine lymphocytes (11). These proteins are formed in limited amounts in polyamine-deficient cells.
KeywordsRibosomal Protein Thymidine Kinase Ribosomal Subunit Thymidine Kinase Gene Thymidine Kinase Activity
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