Two Phases of Ornithine Decarboxylase Activation During Lymphocyte Mitogenesis
Ornithine decarboxylase (ODC) has been implicated in the regulation of cell proliferation (Jänne et al., 1978). ODC is the rate-limiting enzyme in the cellular synthesis of the polyamines (Pegg 1986), which are organic cations required for many growth-related cellular functions (Hölttä et al., 1979, Fillingame et al., 1975). The activity of ODC correlates with the growth rate of cells., Highest activities are usually seen in late G1 phase of the cell cycle and there is a second smaller peak in G2. Malignant transformation is often accompanied by impaired regulation of ODC (Haddox et al., 1980, Sistonen et al., 1987).
KeywordsJurkat Cell Cholera Toxin Pertussis Toxin Ornithine Decarboxylase Rapid Activation
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