Growth-Regulation of the Cellular Levels and Expression of the mRNA Molecules Coding for Ornithine Decarboxylase and S-Adenosylmethionine Decarboxylase
Elevated cellular polyamine levels are required for stimulation of proliferation of normal populations of resting cells (reviewed in Pegg and McCann, 1982; Marton and Morris, 1987). The association between polyamine levels and cell growth has been noted by many workers since the pioneering observations in regenerating liver of Dykstra and Herbst (1965) and Raina and coworkers (1966). Polyamine levels in regenerating liver were shown early to be regulated by the levels of two key enzymes, ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SDC) (Russell and Snyder, 1968; Janne and Raina, 1968; Russell and Lombardini, 1971; Hannonen et al., 1972); these original observations have since been confirmed in a variety of tissue and cell types (reviewed in Pegg and McCann, 1982; Tabor and Tabor, 1984; Pegg, 1986; White and Morris, 1988). In cases where it has been examined, elevation of ODC and SDC levels is primarily a consequence of increased rates of synthesis of the two proteins (Seyfried et al., 1982; Pegg, 1986). In this paper, we discuss the relative contributions of mRNA level and efficiency of mRNA translation to the regulation of the rates of ODC and SDC synthesis. As well, we consider the mechanisms involved in these two modes of regulation and their relationship to pathways of transmembrane mitogenic signal transduction.
KeywordsPhorbol Ester Ornithine Decarboxylase Polyamine Level Ornithine Decarboxylase Activity Lodish Model
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