Characterization and Biogenesis of 5′-Methylthioxylofuranosyl Adenine, a New Natural Analog of 5′-Methylthioadenosine

  • Marina Porcelli
  • Giovanna Cacciapuoti
  • Guido Cimino
  • Margherita Gavagnin
  • Guido Sodano
  • Vincenzo Zappia
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 250)

Abstract

5′-Deoxy-5′-methylthioadenosine (MTA) is a naturally occurring sulfur nucleoside, ubiquitously distributed in nature endowed with antiproliferative activity (1–4). It derives from S-adenosylmethionine (AdoMet) metabolism through several metabolic pathways (1–4). In mammalian tissues the spermidine synthase and spermine synthase reactions represent the quantitatively most important routes for MTA formation (1–4). In spite of the occurrence of multiple biosynthetic pathways, the intracellular concentration of MTA is remarkably low when compared with that of spermidine, spermine and AdoMet (5–8). The thioether indeed does not accumulate intracellular ly because of its rapid cleavage by MTA phosphorylase into adenine and 5-methylthio-ribose-1-phosphate (9).

Keywords

Adenosine Xylose Methionine Aspergillus Adenine 

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Marina Porcelli
    • 1
  • Giovanna Cacciapuoti
    • 1
  • Guido Cimino
    • 1
    • 2
  • Margherita Gavagnin
    • 1
    • 2
  • Guido Sodano
    • 1
    • 3
  • Vincenzo Zappia
    • 1
  1. 1.Istituto di Biochimica delle Macromolecole, I Facoltà di Medicina e ChirurgiaUniversità di NapoliItaly
  2. 2.Istituto per la Chimica di Molecole di Interesse BiologicoCNRNapoliItaly
  3. 3.Istituto di ChimicaUniversità della BasilicataPotenzaItaly

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