Physico-Chemical and Immunological Properties of Bovine Liver 5′-Deoxy-5′-Methylthioadenosine Phosphorylase
The search for specific enzymatic reactions which can clearly differentiate normal mammalian cells from both malignant cells and infective microorganisms represents a major strategy for the development of selective therapeutical approaches. In particular, the intensive research carried out in the past on purine and pyrimidine metabolism has yielded a very rich harvest of drugs effective in the treatment of malignancy as well as of parasitic diseases.
KeywordsHuman Placenta Bovine Liver Purine Nucleoside Phosphorylase Phosphorylase Activity Frictional Ratio
Unable to display preview. Download preview PDF.
- 2.J.A. Duerre, A hydrolytic nucleosidase acting on S-adenosylhomocysteine and on 5′-methylthioadenosine, J. Biol. Chem. 237: 3737 (1962)Google Scholar
- 14.S. Shimizu, T. Abe, S. Shiozaki and H. Yamada, Catabolism of methylthioadenosine and S-adenosylhomocysteine in microorganisms, in International Conference on Polyamines in Life Sciences, Lake Yamanaka, Japan, July 14–18 (1986)Google Scholar